Stereoselective hydroxylation of ethylbenzene to (R)-1-phenylethanol using mycelia of Aspergillus niger as catalyst

The mycelia of Aspergillus niger MTCC-404 have been shown to act as a biocatalyst for the transformation of ethylbenzene to (R)-1-phenylethanol in 99% enantiomeric excess. 72% of the products are (R)-1-phenylethanol. The conversion yield is dependent on pH, temperature and mycelia concentration in s...

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Bibliographic Details
Published inCatalysis communications Vol. 12; no. 9; pp. 781 - 784
Main Authors Yadav, Saroj, Yadav, Rama S.S., Yadava, Sudha, Yadav, Kapil D.S.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 30.04.2011
Subjects
Alkylbenzene
Aspergillus niger
Benzylic hydroxylation
Biocatalyst
Chiral alcohol
Oxygenase
Oxygenase
Alkylbenzene
Benzylic hydroxylation
Aspergillus niger
Chiral alcohol
Biocatalyst
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Summary:The mycelia of Aspergillus niger MTCC-404 have been shown to act as a biocatalyst for the transformation of ethylbenzene to (R)-1-phenylethanol in 99% enantiomeric excess. 72% of the products are (R)-1-phenylethanol. The conversion yield is dependent on pH, temperature and mycelia concentration in suspension. A. niger MTCC-404 facilitates methylbenzene transformation to benzylalcohol, and propylbenzene to 1-phenylpropanol. Therefore, A. niger serves as a biocatalyst for hydroxylation of alkylbenzene's benzylic position. Ethylbenzene has been stereoselectively hydroxylated to (R)-1-phenylethanol using the mycelia of Aspergillus niger MTCC-404 as a biocatalyst. [Display omitted] ►Stereoselective hydroxylation of ethylbenzene has been achieved. ►(R)-1-phenylethanol in 99% enantiomeric execess has been prepared. ►Aspergillus niger MTCC-404 mycelia have been used as a biocatalyst. ►This mycro-organism has a potential for benzylic hydroxylation of alkylbenzenes.
ISSN:1566-7367
1873-3905
DOI:10.1016/j.catcom.2011.01.020