Cohesin RAD21 Gene Promoter Methylation in Patients with Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in adults and is characterized by the presence of specific cytogenetic abnormalities. CLL research has been focused on epigenetic processes like gene promoter methylation of CpG islands. In the present study, the methylation stat...

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Published inCytogenetic and genome research Vol. 154; no. 3; p. 126
Main Authors Ioannidou, Agapi, Zachaki, Sophia, Karakosta, Maria, Daraki, Aggeliki, Roussou, Paraskevi, Manola, Kalliopi N
Format Journal Article
LanguageEnglish
Published Switzerland 2018
Subjects
Chromosomal abnormalities
Chronic lymphocytic leukemia
Methylation
RAD21 gene
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Summary:Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in adults and is characterized by the presence of specific cytogenetic abnormalities. CLL research has been focused on epigenetic processes like gene promoter methylation of CpG islands. In the present study, the methylation status of the RAD21 gene is studied and associated with cytogenetic findings in CLL patients in order to investigate its possible implication in CLL pathogenesis and the formation of CLL chromosomal abnormalities.
ISSN:1424-859X
DOI:10.1159/000487868