Antibiotics from Basidiomycetes. XVI. Antimicrobial and cytotoxic polyines from Mycena viridimarginata Karst

Two new biologically active polyines were isolated from cultures of the fungus Mycena viridimarginata. Their structures were elucidated by spectroscopic and chemical methods as 10-hydroxy-undeca-2,4,6,8-tetraynamide (1) and 3,4,13-trihydroxy-tetradeca-5,7,9,11-tetraynoic acid-gamma-lactone (2). The...

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Bibliographic Details
Published inArchives of microbiology Vol. 132; no. 2; pp. 194 - 196
Main Authors Bauerle, J, Anke, T, Jente, R, Bosold, F
Format Journal Article
LanguageEnglish
Published Germany 01.08.1982
Subjects
Alkynes - biosynthesis
Alkynes - pharmacology
Animals
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Basidiomycota - metabolism
Carcinoma, Ehrlich Tumor
Cell Division - drug effects
Cell Line
DNA - biosynthesis
fungi
Fungi - drug effects
Polyunsaturated Alkamides
Polyynes
Protein Biosynthesis
RNA - biosynthesis
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Summary:Two new biologically active polyines were isolated from cultures of the fungus Mycena viridimarginata. Their structures were elucidated by spectroscopic and chemical methods as 10-hydroxy-undeca-2,4,6,8-tetraynamide (1) and 3,4,13-trihydroxy-tetradeca-5,7,9,11-tetraynoic acid-gamma-lactone (2). The main component (1) is highly antibiotically active and cytotoxic.
ISSN:0302-8933
1432-072X
DOI:10.1007/BF00508730