Cu(OTf) 2-catalyzed synthesis of imidazo[1,2- a]pyridines from α-diazoketones and 2-aminopyridines

• Published in: Tetrahedron letters Vol. 48; no. 43; pp. 7717 - 7720
• Main Authors: Yadav, J.S., Subba Reddy, B.V., Gopal Rao, Y., Srinivas, M., Narsaiah, A.V.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 22.10.2007
• Subjects: Carbene insertion reactions; Imidazo[1,2- a]pyridines; α-Diazoketones; Carbene insertion reactions; α-Diazoketones; Imidazo[1,2- a]pyridines

α-Diazoketones undergo smooth coupling with 2-aminopyridines in the presence of 10 mol % of copper(II) triflate to produce the corresponding 2-substituted imidazo[1,2- a]pyridines (IPs) in excellent yields with high selectivity. Rh 2(OAc) 4 is also found to be an equally effective catalyst for this...