Cu(OTf) 2-catalyzed synthesis of imidazo[1,2- a]pyridines from α-diazoketones and 2-aminopyridines

α-Diazoketones undergo smooth coupling with 2-aminopyridines in the presence of 10 mol % of copper(II) triflate to produce the corresponding 2-substituted imidazo[1,2- a]pyridines (IPs) in excellent yields with high selectivity. Rh 2(OAc) 4 is also found to be an equally effective catalyst for this...

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Bibliographic Details
Published inTetrahedron letters Vol. 48; no. 43; pp. 7717 - 7720
Main Authors Yadav, J.S., Subba Reddy, B.V., Gopal Rao, Y., Srinivas, M., Narsaiah, A.V.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 22.10.2007
Subjects
Carbene insertion reactions
Imidazo[1,2- a]pyridines
α-Diazoketones
Carbene insertion reactions
α-Diazoketones
Imidazo[1,2- a]pyridines
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Summary:α-Diazoketones undergo smooth coupling with 2-aminopyridines in the presence of 10 mol % of copper(II) triflate to produce the corresponding 2-substituted imidazo[1,2- a]pyridines (IPs) in excellent yields with high selectivity. Rh 2(OAc) 4 is also found to be an equally effective catalyst for this transformation.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2007.08.090