Comparison of effects of angiotensin and norepinephrine on pulmonary circulation, systemic arteries and veins, and systemic vascular capacity in the dog

In dog experiments, angiotensin II and norepinephrine were compared in regard to some components of the generalized pressor response each of these agents produces. It was found that angiotensin II has no direct effect on pulmonary blood vessels, in contrast to the pulmonary vasoconstrictor effect of...

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Bibliographic Details
Published inCirculation (New York, N.Y.) Vol. 25; no. 1; pp. 247 - 252
Main Authors ROSE, J C, KOT, P A, COHN, J N, FREIS, E D, ECKERT, G E
Format Journal Article
LanguageEnglish
Published United States 01.01.1962
Subjects
Angiotensin Amide - pharmacology
Angiotensins
Animals
Arteries
Blood Circulation - pharmacology
Cardiovascular System
Dogs
Norepinephrine - pharmacology
Old Medline
Pulmonary Artery - pharmacology
Pulmonary Circulation
Veins
NOREPINEHRINE/pharmacology
HYPERTENSIN/pharmacology
PULMONARY ARTERY/pharmacology
BLOOD CIRCULATION/pharmacology
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Summary:In dog experiments, angiotensin II and norepinephrine were compared in regard to some components of the generalized pressor response each of these agents produces. It was found that angiotensin II has no direct effect on pulmonary blood vessels, in contrast to the pulmonary vasoconstrictor effect of norepinephrine. Angiotensin II appeared to have no effects on veins or the systemic vascular capacity, while norepinephrine was a potent venoconstrictor with, therefore, a marked ability to reduce the systemic vascular capacity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.25.1.247