The effect of zoledronic acid and denosumab on the mandible and other bones: a 18F-NaF-PET study

• Published in: Oral radiology Vol. 38; no. 4; pp. 594 - 600
• Main Authors: Fushimi, Mao, Ohbayashi, Yumiko, Nakai, Fumi, Norikane, Takashi, Yamamoto, Yuka, Nishiyama, Yoshihiro, Miyake, Minoru
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.10.2022; Springer Nature B.V
• Subjects: Bone remodeling; Bone turnover; Bones; Dentistry; Imaging; Mandible; Medicine; Metabolism; Monoclonal antibodies; Oral and Maxillofacial Surgery; Original Article; Radiology; Sodium fluoride; Thorax; Vertebrae; Zoledronic acid; F-NaF-PET; Bisphosphonate; Denosumab; Bone metabolism; Osteonecrosis of jaw
• ISSN: 0911-6028; 1613-9674
• DOI: 10.1007/s11282-022-00594-2

Objectives The primary purpose of this study was to determine whether both zoledronic acid (ZA) and denosumab (Dmab) equally suppress bone remodeling of the normal mandible, and the secondary purpose was to determine the influence of ZA and Dmab on other normal bones. Methods 18 F-sodium fluoride-positron-emission-tomography ( 18 F-NaF-PET) was used to perform quantitative analysis of the bone metabolism in various parts. The end points of the study were the mean standardized uptake value (SUV) of each member of the ZA group ( n  = 9), the Dmab group ( n  = 16), and the Control group ( n  = 23). Results The SUV at the thoracic vertebrae in the ZA group were significantly lower than those of the Dmab and Control group ( p  < 0.05) In addition, the mean SUVs of the cervical vertebrae in the ZA group were significantly lower than those in the Control group ( p  < 0.05). There was no significant difference among ZA, Dmab and Control group in the other sites. There was no significant difference between the Dmab and Control groups at all sites. Conclusions The remodeling of mandible was not suppressed due to the treatment with anti-resorptive agents. Differences in the mechanisms of action between the BP and Dmab caused the specificity of the effect on the metabolism of normal bone.