Histocompatibility of Thermopolymerized Denture Base Copolymer Processed with a Novel Ring-opening Oxaspiro Comonomer: A Histomorphometric Investigation in Rats

• Published in: The journal of contemporary dental practice Vol. 22; no. 11; pp. 1281 - 1286
• Main Authors: Ajay, Ranganathan, Sasikala, Ramajayam, Divagar, Chandrasekaran, Solomon, Boaz Ebenezer, Anand, Velayudhan, Khalid, Ghiaz
• Format: Journal Article
• Language: English
• Published: India 01.11.2021
• Subjects: Animals; Denture Bases; Histocompatibility; Materials Testing; Polymers; Prospective Studies; Rats; Denture; Comonomer; Histocompatibility; Initiation Ring-opening
• ISSN: 1526-3711; 1526-3711
• DOI: 10.5005/jp-journals-10024-3182

The aim of the research was to evaluate the histocompatibility of thermopolymerized (TP) novel denture copolymer containing 3,9-dimethylene-1,5,7,11-tetraoxaspiro[5,5]undecane (DMTOSU) comonomer in rats' palatine tissue. The rats were randomly categorized into four groups ( = 6 per group). G : Denture base appliance (DBA) fabricated by short polymerization cycle in a water bath without DMTOSU; G : DBA with 20 wt.% DMTOSU polymerized at 70°C for 2 hours followed by short polymerization cycle in a water bath; G : DBA with 20 wt.% DMTOSU polymerized at 60°C for 45 minutes followed by 130°C for 20 minutes in an autoclave; and Group NC (negative control): rats with no DBA. The rats were euthanized after 2 weeks and the palatal tissues were subjected to histological examination. Epithelial thickness (ET), connective tissue thickness (CT), and keratin layer thickness (KT) were measured. G exhibited greater ET, CT, and KT than the other groups. The ET and KT of G were significantly lesser than G . Multiple comparisons exhibited significant differences between the groups, except for G and G concerning the CT. The novel denture copolymer containing 20 wt.% of DMTOSU comonomer is histocompatible with rats' palatine tissue. As DMTOSU is a double-ring-opening antishrinking oxaspiro monomer, its incorporation in TP-DBR would result in dimensionally accurate and stable dentures without endangering the biocompatibility in the prospective years.