Synthesis, characterization, and antibacterial activity of novel Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with vitamin K3-thiosemicarbazone

• Published in: Journal of inorganic biochemistry Vol. 78; no. 2; pp. 167 - 174
• Main Authors: Li, Q X, Tang, H A, Li, Y Z, Wang, M, Wang, L F, Xia, C G
• Format: Journal Article
• Language: English
• Published: United States 30.01.2000
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Bacillus - drug effects; Escherichia coli - drug effects; Ligands; Metals - chemistry; Microbial Sensitivity Tests; Molecular Structure; Staphylococcus aureus - drug effects; Thiosemicarbazones - chemistry; Thiosemicarbazones - pharmacology; Vitamin K - chemistry; Vitamin K - pharmacology
• ISSN: 0162-0134
• DOI: 10.1016/S0162-0134(99)00226-3

Vitamin K3-thiosemicarbazone (C12H11N3NaO4S2 x 5H2O, abbreviated as VT), a new Schiff base derivative, has been synthesized. Its crystal structure, determined by X-ray diffraction, is triclinic, space group P1. We have also prepared five novel complexes of VT with transition metals: [M(VT)(2)2H2O] x nH2O, (n = 1 and 2 for M = Cu(II) and Zn(II), respectively) and [M'(HVT)2Cl2] x mH2O, (m = 4, 5, and 7 for M' = Co(II), Mn(II), and Ni(II), respectively). These compounds were characterized by IR and UV-Vis spectroscopy, molar conductivity, thermal analyses, complexometric titration, and elemental analysis. In all the complexes, the VT ligand coordinates through sulfur and oxygen atoms, and the geometry around metal atom is best described as octahedral. In vitro tests of antibacterial activity showed that VT and its complexes with Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) all had strong inhibitory actions against G(+) Staphylococcus aureus, G(+) Hay bacillus, and G(-) Escherichia coli.