Some estrogenic effects of two oral contraceptives consisting of norgestrel and two different doses of ethynylestradiol

• Published in: Contraception (Stoneham) Vol. 20; no. 1; pp. 5 - 10
• Main Authors: Miller, J.F., Fotherby, K., Bye, P.G.T., Elstein, Max
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.1979
• Subjects: Adolescent; Adult; Ceruloplasmin; Cervix Mucus; Contraceptives, Oral; Estrogens - pharmacology; Ethinyl Estradiol - pharmacology; Female; Humans; Norgestrel - blood; Norgestrel - pharmacology; Population; Sex Hormone-Binding Globulin; Hemic System; Contraceptive Agents, Estrogen > analysis; Contraceptive Agents, Estrogen > administraction and dosage; Biology; Research Methodology; Contraceptive Agents, Progestin > analysis; Urogenital System; Contraceptive Agents > side effects; Contraceptive Agents, Female > administraction and dosage; Oral Contraceptives, Combined; Uterus; Contraceptive Agents, Female > analysis; Physiology; Oral Contraceptives; Ethinyl Estradiol > analysis; Genitalia; Ethinyl Estradiol > administraction and dosage; Contraceptive Agents > administraction and dosage; Uterine Effects; Statistical Studies; Contraception; Correlation Studies; Ethinyl Estradiol > side effects; Cervix; Contraceptive Agents, Estrogen > side effects; Family Planning; Cervical Mucus > analysis; Genitalia, Female; Studies; Hematological Effects; Contraceptive Agents > analysis; Immunoglobulin Alterations; Contraceptive Agents, Female > side effects
• ISSN: 0010-7824; 1879-0518
• DOI: 10.1016/0010-7824(79)90039-8

Some biological and biochemical effects (ie. KPI, cervical mucus, SHBG and ceruloplasmin) as well as serum ethynylestradiol and serum norgestrel, following the use of two oral contraceptives containing the same amount of norgestrel (dl-norgestrel 0.5 mg) and either 30 μg or 50 μg of ethynylestradiol were compared. There was no difference in the clinical features in either group of patients. There was a statistically significant difference in the levels of unconjugated ethynylestradiol but not in the other biochemical parameters studied. It is concluded that the absence of any such difference might be attributable to the strong antiestrogenic effects of dl-norgestrel.