Possibilities of therapeutic correction of ENT pathology associated with COVID-19 in children on an outpatient basis

• Published in: Vestnik otorinolaringologii Vol. 86; no. 6; p. 69
• Main Authors: Golovacheva, E G, Afanasyeva, O I, Goncharova, E S, Bykovskaya, A G, Davletgareeva, D V, Apryatina, V A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2021
• Subjects: Adolescent; Antiviral Agents - therapeutic use; Child; Child, Preschool; COVID-19 - drug therapy; COVID-19 - prevention & control; Humans; Infant; Outpatients; Post-Exposure Prophylaxis; Retrospective Studies; COVID-19; Cytovir-3; outpatient treatment; children; anosmia
• ISSN: 0042-4668
• DOI: 10.17116/otorino20218606169

To evaluate the therapeutic and preventive efficacy of the drug with antiviral and immunotropic activity Cytovir-3 in children with COVID-19 on an outpatient basis. A retrospective analysis the treatment of 52 pediatric patients aged 1 to 17 years with a confirmed new coronavirus infection SARS-CoV-2 with the drug Cytovir-3 was carried out. 28 people, contacts in the family, received the drug for prophylactic purposes. Clinical observation of patients was carried out with an assessment of the severity and duration of fever, the anosmia, catarrhal symptoms in the nasopharynx and analysis indicator of saturation. In the control group, there were 27 patients of the same age who received the medicine Umifenovir and 25 contact family members who did not receive the medicine for prophylactic purposes. The use of Cytovir-3 in the COVID-19 treatment in children led to a decrease in intoxication symptoms 3.2-3.4 days after taking the medicine, a significant reduction of anosmia period recovery time, and elimination of the pathogen according to PCR analysis. The patients receiving the drug did not have ENT- complications and did not require hospitalization. Prophylactic administration of the drug in contact family members statistically significantly reduced the likelihood of developing the disease 3.6 times. The clinical efficacy and feasibility of using Cytovir-3 in the treatment and prevention of new coronavirus infection in patients of different ages has been shown.