Spatial diversity of in vivo tissue immunity

The immune system exhibits spatial diversity in in vivo tissues. Immune cells are strategically distributed within tissues to maintain the organ integrity. Advanced technologies such as intravital imaging and spatial transcriptomics have revealed the spatial heterogeneity of immune cell distribution...

Full description

Saved in:
Bibliographic Details
Published inInternational immunology
Main Authors Miyamoto, Yu, Ishii, Masaru
Format Journal Article
LanguageEnglish
Published England 23.08.2024
Subjects
Tissue immunology
Spatial transcriptomics
Intravital imaging
Online AccessGet full text

Cover

More Information
Summary:The immune system exhibits spatial diversity in in vivo tissues. Immune cells are strategically distributed within tissues to maintain the organ integrity. Advanced technologies such as intravital imaging and spatial transcriptomics have revealed the spatial heterogeneity of immune cell distribution and function within organs such as the liver, kidney, intestine, and lung. In addition, these technologies visualize nutrient and oxygen environments across tissues. Recent spatial analyses have suggested that a functional immune niche is determined by interactions between immune and non-immune cells in an appropriate nutrient and oxygen environment. Understanding the spatial communication between immune cells, environment, and surrounding non-immune cells is crucial for developing strategies to control immune responses and effectively manage inflammatory diseases.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1460-2377
1460-2377
DOI:10.1093/intimm/dxae051