Multidrug resistance Gene-1 polymorphisms (C3435T and G2677T) and the risk of inflammatory bowel disease in Egyptian patients

• Published in: Arab journal of gastroenterology
• Main Authors: Marzaban, Raghda, Mohamed Samy, Rania, Ahmed Kassem, Mona, Atef, Mira
• Format: Journal Article
• Language: English
• Published: Egypt Elsevier B.V 26.02.2024
• Subjects: Crohn’s disease (CD); Inflammatory bowel disease (IBD); Multidrug resistance 1 (MDR1); Single nucleotide polymorphism (SNP); Ulcerative colitis (UC); Inflammatory bowel disease (IBD); Crohn’s disease (CD); Multidrug resistance 1 (MDR1); Ulcerative colitis (UC); Single nucleotide polymorphism (SNP)
• ISSN: 1687-1979; 2090-2387
• DOI: 10.1016/j.ajg.2023.12.008

The multidrug resistance 1 (MDR1) gene is a gene involved in the pathogenesis of inflammatory bowel disease (IBD).The aim of the study is to investigate the association of MDR-1 gene polymorphisms (C2345T and G2677T) and IBD incidence in Egyptian patients, and its relation with disease severity. This is a case-control study where genotyping of MDR-1 gene C3435T and G2677T single nucleotide polymorphisms (SNPs) were assayed. Forty naïve IBD patients, who were composed of 25 UC and 15CD, were compared to 60 healthy controls. They were young aged with significant female predominance, particularly in CD (P = 0.004). UC was mainly (48 %) presented in moderate severity while CD was mainly (53.3 %) presented with mild severity. MDR-1 gene C3435T SNP was not statistically related to IBD, whether in terms of genotypes or alleles, yet its T allele was significantly related to moderate cases of UC (P = 0.014). However, GG genotype of G2677T SNP was significantly low in IBD (P = 0.013), while TT genotype and T allele were significantly related to CD (P = 0.011, and 0.012 respectively). Moreover, G allele proved to be associated significantly with moderate cases of UC (P = 0.001) and mild cases of CD (P = 0.002). MDR-I gene G2677T SNP GG genotype proved to be protective against IBD, thus may be considered in diagnostic workup of IBD including its severity.