Serum Ferritin and PELOD-2 Scores in Critically Ill Septic Children - a Cross-sectional Single-center Study

• Published in: Acta medica Philippina Vol. 58; no. 6; pp. 64 - 68
• Main Authors: Yanni, Gema Nazri, Saragih, Rina Amalia C, Lubis, Aridamuriany Dwiputri
• Format: Journal Article
• Language: English
• Published: Philippines University of the Philippines Manila 2024
• Subjects: Original; ferritin; infection; PELOD-2; sepsis
• ISSN: 0001-6071; 2094-9278
• DOI: 10.47895/amp.vi0.6496

This study aims to assess the correlation of ferritin serum level and PELOD-2 score, and determine the effectiveness of ferritin serum level as early indicator of organ dysfunction. This was a cross-sectional study carried out to pediatric patients with sepsis in the Pediatric Intensive Care Unit Haji Adam Malik and Universitas Sumatera Utara hospital from June 2021 - January 2022. Complete blood work was done, and ferritin serum level and PELOD-2 score were measured on the first and third day of hospital stay of all the sixty participants aged 1-18 years old with sepsis. The correlation was measured using Spearman test, with p<0.05 indicating a significant correlation. The median level of serum ferritin level was 480 (24.7 - 22652) ng/mL. There were 20% patients with ferritin level <200 ng/mL, 26.7% with ferritin level 200-500 ng/mL, and 53.3% patients with ferritin >500 ng/mL. The median score of PELOD-2 was 4. There was a significant correlation of serum ferritin and PELOD-2 score on day 1 of hospital stay. The ferritin serum level is effective as an early indicator of organ dysfunction until PELOD-2 score is established. There is a positive correlation between serum ferritin and PELOD-2 score. There is a link between elevated ferritin and worse disease prognosis.