Biocompatibility of Biodegradable Polymer Films Based on Poly(lactic-co-glycolic acid) of Various Molecular Weights

Various poly(lactic- co -glycolic acid)-based polymeric films with various molecular weights were obtained. The mechanical characteristics of these films were investigated. It was shown that the obtained polymer films do not have a short-term toxic effect on mammalian cells. The percentage of active...

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Published inInorganic materials : applied research Vol. 10; no. 4; pp. 887 - 891
Main Authors Baikin, A. S., Sevost’yanov, M. A., Nasakina, E. O., Sergienko, K. V., Kaplan, M. A., Konushkin, S. V., Kolmakova, A. A., Yakubov, A. D., Bunkin, N. F., Gudkov, S. V., Shatova, L. A., Barinov, S. M., Kolmakov, A. G.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 2019
Springer Nature B.V
Subjects
Biocompatibility
Biodegradability
Chemistry
Chemistry and Materials Science
Glycolic acid
Industrial Chemistry/Chemical Engineering
Inorganic Chemistry
Materials Science
Mechanical properties
Molecular weight
Polymer films
Polymers
polymer films
poly(lactic
biodegradable materials
superelasticity
biocompatibility
glycolic acid
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Summary:Various poly(lactic- co -glycolic acid)-based polymeric films with various molecular weights were obtained. The mechanical characteristics of these films were investigated. It was shown that the obtained polymer films do not have a short-term toxic effect on mammalian cells. The percentage of actively dividing cells on such polymer films is 1.5–3.0 times higher than when grown on culture glass, and, accordingly, the cell layer is formed faster. The obtained poly(lactic- co -glycolic acid)-based polymer films are biocompatible.
ISSN:2075-1133
2075-115X
DOI:10.1134/S207511331904004X