Regulation of hepatocarcinogenesis by microRNAs

Liver cancer (hepatocellular carcinoma, HCC) is a major malignancy worldwide. Etiologically, hepatocarcinogenesis is closely associated with HBV and HCV infections; however, its underlying molecular mechanism is not completely understood. MicroRNAs are a class of small non-coding RNAs that negativel...

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Bibliographic Details
Published inFrontiers in bioscience (Elite edition) Vol. 5; no. 1; p. 49
Main Authors Wong, Chun-Ming, Kai, Alan Ka-Lun, Tsang, Felice Ho-Ching, Ng, Irene Oi-Lin
Format Journal Article
LanguageEnglish
Published Singapore 01.01.2013
Subjects
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - prevention & control
Gene Expression Profiling - methods
Gene Expression Regulation, Neoplastic - genetics
Gene Expression Regulation, Neoplastic - physiology
Genetic Variation
Humans
Liver Neoplasms - metabolism
Liver Neoplasms - prevention & control
MicroRNAs - biosynthesis
MicroRNAs - genetics
MicroRNAs - metabolism
MicroRNAs - therapeutic use
Prognosis
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Summary:Liver cancer (hepatocellular carcinoma, HCC) is a major malignancy worldwide. Etiologically, hepatocarcinogenesis is closely associated with HBV and HCV infections; however, its underlying molecular mechanism is not completely understood. MicroRNAs are a class of small non-coding RNAs that negatively regulate gene expression by interacting with the 3'UTR of protein-coding mRNA. MicroRNAs are implicated in nearly all major biological and cellular events, and recent findings further link microRNA deregulation to human carcinogenesis. In this review, we will focus on the aberrant expression of miRNAs in liver cancer and the pathological implications and molecular functions of some well-characterized oncogenic and tumor suppressive miRNAs. Finally, the clinical prospect of miRNAs as a novel diagnostic and therapeutic intervention will be discussed.
ISSN:1945-0508
DOI:10.2741/e595