Intraosseous fibrous lesions of the jawsA manifestation of tuberous sclerosis

• Published in: Oral surgery, oral medicine, oral pathology, oral radiology and endodontics Vol. 87; no. 3; pp. 334 - 340
• Main Authors: Damm, Douglas D., Tomich, Charles E., White, Dean K., Drummond, James F.
• Format: Journal Article
• Language: English
• Published: Mosby, Inc 01.03.1999
• ISSN: 1079-2104; 1528-395X
• DOI: 10.1016/S1079-2104(99)70219-2

Four patients previously diagnosed with tuberous sclerosis are reported with intraosseous fibrous lesions of the jaws. Review of the literature revealed comparable pathosis occurring in extragnathic bones and several previous reports of similar lesions within the jaws. Therefore, these intraosseous fibrous proliferations are thought to represent an intraoral manifestation of tuberous sclerosis and not coincidental findings. In all 4 cases, the tumors demonstrated significant collagenization with numerous interspersed plump fibroblasts. Although histopathologically similar, the features of the lesions are not specific and also can be found in desmoplastic fibromas and simple odontogenic fibromas. The definitive diagnosis requires appropriate clinicopathologic correlation. ( Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87:334-40)