Morphological and structural responsies of Fusobacterium nucleatum to fosfomycin

The effects of fosfomycin (FOM) on growth, morphology and the fine structure of Fusobacterium nucleatum cells were examined. The minimal inhibitory concentration (MIC) of FOM against F. nucleatum cells growing exponentially was 1.56μglml. Phase-contrast and scanning electron microscopy showed that t...

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Bibliographic Details
Published inJapanese Journal of Oral Biology Vol. 27; no. 3; pp. 782 - 793
Main Authors Kaku, Nobuyuki, Nakai, Yoshikazu, Konakajima, Yuichi, Yoshitake, Hiroyuki, Sagawa, Hirosuke, Onoe, Takatoshi, Hirohata, Kenichi
Format Journal Article
LanguageEnglish
Published Japanese Association for Oral Biology 1985
Subjects
fine structure
fosfomycin
Fusobacterium nucleatum
morphology
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ISSN0385-0137
DOI10.2330/joralbiosci1965.27.782

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Summary:The effects of fosfomycin (FOM) on growth, morphology and the fine structure of Fusobacterium nucleatum cells were examined. The minimal inhibitory concentration (MIC) of FOM against F. nucleatum cells growing exponentially was 1.56μglml. Phase-contrast and scanning electron microscopy showed that the cells were elongated by exposure to 1/2 MIC of FOM, and vesicles were formed on the cells above the MIC. Transmission electron microscopy revealed that the vesicle was consisted of outer membrane only or outer membrane, cytoplasmic membrane and cytoplasm. Other changes in the cell structure than those mentioned above included invagination of outer membrane, cytoplasmic division and protoplast formation. It seems that the vesicle formation and the invagination of outer membrane are the structural changes related to cell lysis by FOM.
ISSN:0385-0137
DOI:10.2330/joralbiosci1965.27.782