In vivo cytokine production in murine listeriosis. Evidence for immunoregulation by gamma delta+ T cells

• Published in: The Journal of immunology (1950) Vol. 156; no. 1; pp. 232 - 237
• Main Authors: Hsieh, B, Schrenzel, MD, Mulvania, T, Lepper, HD, DiMolfetto-Landon, L, Ferrick, DA
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.01.1996
• Subjects: Animals; Cytokines - biosynthesis; Immunization, Secondary; Interferon-gamma - biosynthesis; Interleukin-10 - biosynthesis; Interleukin-4 - biosynthesis; Listeriosis - immunology; Listeriosis - metabolism; Listeriosis - therapy; Mice; Mice, Inbred C3H; Receptors, Antigen, T-Cell, gamma-delta - immunology; Splenic Diseases - immunology; Splenic Diseases - metabolism; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism
• ISSN: 0022-1767; 1550-6606
• DOI: 10.4049/jimmunol.156.1.232

Differential cytokine production by gamma delta+ T cells influences Th1 and Th2 responses. Here, we describe the in vivo kinetics of peritoneal and splenic gamma delta+, CD4+, and CD8+ T cell cytokine responses during primary and secondary Listeria infections. The data show differences in the kinetics of IFN-gamma-producing alpha beta+ splenocytes consistent with immunologic memory. Most noteworthy, however, was the elevated production of IL-10 by splenic gamma delta+ T cells in the red pulp and marginal zones that coincided with maximal IFN-gamma production and with a decrease in inflammation and tissue damage. This result implies a role for gamma delta+ T cells in the control of Th1 responses.