A Case of Ulcerative Colitis with Elevated Serum Amylase and Alkaline-phoshatase

• Published in: Nippon Daicho Komonbyo Gakkai Zasshi Vol. 39; no. 2; pp. 162 - 166
• Main Authors: Murata, M., Chiba, M., Ihzuka, M., Arakawa, H., Masamune, O.
• Format: Journal Article
• Language: English
• Published: The Japan Society of Coloproctology 1986
• ISSN: 0047-1801; 1882-9619
• DOI: 10.3862/jcoloproctology.39.162

A fourteen years old girl with ulcerative colitis (pancolitis, the first attack) had elevated serum amylase and alkaline-phosphatase. The analysis of isozyme of amylase revealed a predominance of S type and serum level of amylase was unrelated to the activity of colitis. As she had no sign or laboratory finding indicating pancreatitis, hepatic disease, pneumonia etc which are often associated with elevated serum amylase, the elevation of serum amylase was considered as that associated with ulcerative colitis. Serum amylase elevated more each after repeated colonoscopy probably due to mechanical stimulation of releasing amylase from the intestine. Serum alkaline-phosphatase returned to normal when remission was obtained and analysis of isozyme of alkaline-phosphatase showed a broad zone of the activity toward the cathode of alkaline-phosphatase-3 indicating alkaline-phosphatase-6. Retrospective studies of frequency of continuous elevated serum amylase in our 37 (including this case) cases with ulcerative colitis was 5.4 percent (2 out of 37) and that of elevated alkaline-phosphatase suggestive of alkaline-phosphatase-6 by analysis of alkaline-phosphatase isozyme was 20 percent (3/15).The frequency and significance of the elevated serum amylase and alkaline-phosphatase in the literature are presented.