Effects of Kanpyo Powder on the Drug-Metabolizing System of Rats Treated with Amaranth

Male rats were fed a diet supplemented with 2% amaranth and/or 10% Kanpyo powder for 30 days. Hepatic cytochrome P-450 content and arylhydrocarbon hydroxylase, UDP-glucuronosyltransferase (UDPGT), sulfotransferase and glutathione S-transferase (GST) activities, as well as intestinal UDPGT and GST ac...

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Published inFood Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) Vol. 35; no. 6; pp. 610 - 614_1
Main Authors IITOI, Yoji, ITOH, Masahiko, IWAMA, Masahiko, IWASAKI, Masae, KANKE, Yusuke, KENMOKU, Akitsugu
Format Journal Article
LanguageEnglish
Published Japanese Society for Food Hygiene and Safety 1994
Subjects
amaranth
diarrhea
dietary fiber
glutathione S-transferase
Kanpyo powder
UDP-glucuronosyltransferase
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Summary:Male rats were fed a diet supplemented with 2% amaranth and/or 10% Kanpyo powder for 30 days. Hepatic cytochrome P-450 content and arylhydrocarbon hydroxylase, UDP-glucuronosyltransferase (UDPGT), sulfotransferase and glutathione S-transferase (GST) activities, as well as intestinal UDPGT and GST activities, were determined. Among the enzymes, only intestinal microsomal UDPGT activity was significantly lowered by amaranth, and this effect was prevented by the addition of Kanpyo powder. Rats fed Kanpyo diet showed a significant increase in hepatic GST activity compared to the untreated rats, regardless of amaranth addition. These data suggest that Kanpyo powder might modify the drugmetabolizing enzyme system, and thus contribute to protection of rats from the harmful effects of xenobiotic compounds such as amaranth.
ISSN:0015-6426
1882-1006
DOI:10.3358/shokueishi.35.610