Plasmic degradation of fibrinogen: The preparation of a low molecular weight derivative of Fragment D

The conditions for the formation of a low molecular weight Fragment D (Fragment d) have been elucidated. Fragment D undergoes an irreversible conformational change on incubation at pH values below 3.5. This change leaves Fragment D more susceptible to additional plasmic digestion. Methods for the pu...

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Bibliographic Details
Published inThrombosis research Vol. 3; no. 5; pp. 553 - 564
Main Authors Kemp, Graham, Furlan, Miha, Beck, Eugene A.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 1973
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Summary:The conditions for the formation of a low molecular weight Fragment D (Fragment d) have been elucidated. Fragment D undergoes an irreversible conformational change on incubation at pH values below 3.5. This change leaves Fragment D more susceptible to additional plasmic digestion. Methods for the purification of Fragments E, D and d are described.
ISSN:0049-3848
1879-2472
DOI:10.1016/0049-3848(73)90116-3