Does the malonyl-coenzyme A:21-hydroxypregnane 21-hydroxymalonyltransferase catalyze the first step in the formation of the butenolide ring of cardenolides?
An enzyme catalyzing the transfer of the malonyl moiety from malonyl-coenzyme A 1 to the 21-hydroxy group of 3β,14β,21-trihydroxy-5β-pregnane-20-one 2 was isolated from Digitalis lanata leaves and characterized. The role of this particular enzyme in cardenolide biosynthesis is discussed. A new mecha...
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| Published in | Tetrahedron letters Vol. 37; no. 13; pp. 2221 - 2224 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Ltd
25.03.1996
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| Online Access | Get full text |
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| Summary: | An enzyme catalyzing the transfer of the malonyl moiety from malonyl-coenzyme A
1 to the 21-hydroxy group of 3β,14β,21-trihydroxy-5β-pregnane-20-one
2 was isolated from
Digitalis lanata leaves and characterized. The role of this particular enzyme in cardenolide biosynthesis is discussed.
A new mechanism of butenolide ring formation via a pregnane 21-malonyl hemi-ester is proposed. |
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| ISSN: | 0040-4039 1873-3581 |
| DOI: | 10.1016/0040-4039(96)00276-6 |