The in vitro unscheduled DNA synthesis (UDS) assay in rat primary hepatocytes: Evaluation of 2-furoic acid and 7 drug candidates

The in vitro unscheduled DNA synthesis assay (UDS) is part of the routine genetic toxicology screening at The Upjohn Company. The purpose of this paper is to report results for 8 compounds which were tested in the in-house genetic toxicology program. These compounds represent diverse chemical struct...

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Bibliographic Details
Published inMutation Research/Genetic Toxicology Vol. 223; no. 2; pp. 163 - 169
Main Authors Aaron, C.S., Harbach, P.R., Wiser, S.K., Grzegorczyk, C.R., Smith, A.L.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 1989
Subjects
2-Furoic acid
assay
DNA synthesis
Hepatocytes
in vitro
rat primary
UDS assay
unscheduled
unscheduled
Hepatocytes
assay
in vitro
UDS assay
DNA synthesis
2-Furoic acid
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Summary:The in vitro unscheduled DNA synthesis assay (UDS) is part of the routine genetic toxicology screening at The Upjohn Company. The purpose of this paper is to report results for 8 compounds which were tested in the in-house genetic toxicology program. These compounds represent diverse chemical structure and most of them entered the screening program because they are biologically active in efficacy screens. All tests were carried out under Good Laboratory Practices Regulations of the U.S. Food and Drug Administration. None of the materials reported here produced an increase in UDS and therefore the UDS results with these compounds do not suggest potential for genotoxicity.
ISSN:0165-1218
DOI:10.1016/0165-1218(89)90044-X