Structural determination of three neutral oligosaccharides in bovine (Holstein-Friesian) colostrum, including the novel trisaccharide; GalNAcαl-3Galβ1-4Glc

Two trisaccharides, and a pentasaccharide were obtained from bovine colostrum. Their chemical structures were determined by using methylation and 13C-NMR analyses as follows: GalNacα1-3Galβ1-4Glc, Galα-1-3Galβ1-4Glc, Galβ1-3[Galβ1-4GlcNAcβ1-6]Galβ1-4Glc. GalNAcα1-3Galβ1-4Glc, which was identified in...

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Published inBiochimica et biophysica acta. General subjects Vol. 1073; no. 1; pp. 225 - 229
Main Authors Tadasu Urashima, Tadao Saito, Kenzi Ohmisya, Keiichi Shimazaki
Format Journal Article
LanguageEnglish
Published Elsevier B.V 23.01.1991
Subjects
Carbohydrate structure
Colostrum, bovine
NMR, 13C
Oligosaccharide, neutral
α-d-GalNAc unit
Oligosaccharide, neutral
Colostrum, bovine
α-d-GalNAc unit
Carbohydrate structure
NMR, 13C
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Summary:Two trisaccharides, and a pentasaccharide were obtained from bovine colostrum. Their chemical structures were determined by using methylation and 13C-NMR analyses as follows: GalNacα1-3Galβ1-4Glc, Galα-1-3Galβ1-4Glc, Galβ1-3[Galβ1-4GlcNAcβ1-6]Galβ1-4Glc. GalNAcα1-3Galβ1-4Glc, which was identified in this study, is a novel oligosaccharide from natural sources. Galα1-3Galβ1-4Glc and Galβ1-3[Galβ1-4GlcNAcβ1-6]Galβ1-4Glc (lacto-N-novopentaose) have been already found in ovine colostrum, and in horse colostrum and marsupial milk, respectively.
ISSN:0304-4165
1872-8006
DOI:10.1016/0304-4165(91)90207-W