Mammalian U87 Small Nucleolar RNA and Its Host Gene

Most small nucleolar RNAs (snoRNAs) of the C/D box family determine the site of ribose methylation in rRNA. A new snoRNA, U87, was found in mammals, assigned to the C/D box family, and assumed to play a role in ribose methylation at G3468 of the 28S rRNA. The U87 host gene (U87HG), with an intron co...

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Bibliographic Details
Published inMolecular biology (New York) Vol. 39; no. 4; pp. 564 - 571
Main Authors Makarova, J. A., Kramerov, D. A.
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.07.2005
Subjects
Bacteria
Conservation
Conserved sequence
Exons
Genes
Introns
Nucleoli
Nucleotides
Open reading frames
Polyadenylation
Ribose
rRNA
rRNA 28S
snoRNA
Splicing
Transcription
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Summary:Most small nucleolar RNAs (snoRNAs) of the C/D box family determine the site of ribose methylation in rRNA. A new snoRNA, U87, was found in mammals, assigned to the C/D box family, and assumed to play a role in ribose methylation at G3468 of the 28S rRNA. The U87 host gene (U87HG), with an intron coding for the U87 snoRNA, was described for rodents and humans. Transcription of the human gene starts from three adjacent nucleotides, while the rat gene harbors multiple transcription start sites. The U87HG RNA resembles mRNA in some features (splicing, polyadenylation, and cytoplasmic localization) but lacks an extended open reading frame and shows a considerably lower level of conservation as compared with mRNAs of most other snoRNA host genes. The low conservation of the mRNA-like transcript of U87HG is discussed in terms of the functional significance of its exons.[PUBLICATION ABSTRACT]
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ISSN:0026-8933
1608-3245
DOI:10.1007/s11008-005-0072-2