Identification of a third form of protein phosphatase 1 in rabbit skeletal muscle that is associated with myosin

A third form of protein phosphatase 1 has been identified in skeletal muscle which is distinct from the species composed of the catalytic subunit complexed to the glycogen-binding subunit (protein phosphatase 1 G) or inhibitor-2 (protein phosphatase 1 I). The third form has an apparent molecular mas...

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Published inBiochimica et biophysica acta. Molecular cell research Vol. 968; no. 3; pp. 392 - 400
Main Authors Chisholm, Alexander A.K., Cohen, Philip
Format Journal Article
LanguageEnglish
Published Elsevier B.V 11.03.1988
Subjects
Glycogen binding
Glycogen metabolism
Myosin binding
Protein phosphatase 1
Skeletal muscle
Myosin binding
Protein phosphatase 1
Glycogen binding
Skeletal muscle
Glycogen metabolism
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Summary:A third form of protein phosphatase 1 has been identified in skeletal muscle which is distinct from the species composed of the catalytic subunit complexed to the glycogen-binding subunit (protein phosphatase 1 G) or inhibitor-2 (protein phosphatase 1 I). The third form has an apparent molecular mass of 110 kDa, is not immunoprecipitated by antibody prepared against the glycogen-binding subunit, does not interact with glycogen and is devoid of inhibitor-2. It is tightly bound to myosin and is therefore termed protein phosphatase 1 M.
ISSN:0167-4889
1879-2596
DOI:10.1016/0167-4889(88)90032-8