Preventive effect of pyrroloquinoline quinone (PQQ) on bilivedrin accumulation of the liver of chick embryo after glucocorticoid administration

Administration of a high dose of hydrocortisone hemisuccinate sodium (0.25 μmol/egg) to 15-day-old fertilized hen's eggs caused accumulation of biliverdin in the embryonic liver. The responses were 10 to 20-fold higher than controls within 48 hr as a result of stimulation of biliverdin synthesi...

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Published inLife sciences (1973) Vol. 52; no. 3; pp. 305 - 312
Main Authors Nishigori, Hideo, Ishida, Osamu, Ogihara-Umeda, Izumi
Format Journal Article
LanguageEnglish
Published Elsevier Inc 1993
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Summary:Administration of a high dose of hydrocortisone hemisuccinate sodium (0.25 μmol/egg) to 15-day-old fertilized hen's eggs caused accumulation of biliverdin in the embryonic liver. The responses were 10 to 20-fold higher than controls within 48 hr as a result of stimulation of biliverdin synthesis in the liver and the decrease of biliverdin excretion from the liver. This accumulation was effectively prevented by PQQ, possibly through the enhancement of biliverdin excretion from the liver to the gallbladder. This PQQ action was due to its preventive effect against the decrease of glutathione in the liver caused by glucocorticoid since glutathione is suggested to play a role in elimination of bile components from the liver.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(93)90222-O