Evidence of a short-term effect of growth hormone on in vivo bone protein synthesis in normal rats

The growth of skeletal tissue is influenced by growth hormone (GH), whose effects are believed to be mediated, at least in part, by somatomedins or insulin-like growth factors (IGFs). This report describes an action of GH by increasing bone protein synthesis. This effect was not accompanied by chang...

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Bibliographic Details
Published inBiochimica et biophysica acta. Molecular cell research Vol. 1093; no. 1; pp. 111 - 113
Main Authors Alfredo Martínez, J., Del Barrio, Antonio S., Larralde, Jesús
Format Journal Article
LanguageEnglish
Published Elsevier B.V 07.06.1991
Subjects
Bone protein synthesis
Growth hormone
Somatomedin
Bone protein synthesis
GH
Somatomedin
IGF
Growth hormone
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Summary:The growth of skeletal tissue is influenced by growth hormone (GH), whose effects are believed to be mediated, at least in part, by somatomedins or insulin-like growth factors (IGFs). This report describes an action of GH by increasing bone protein synthesis. This effect was not accompanied by changes in circulating IGFs. It is concluded that this experiment shows apparently for the first time in intact animals a short-term effect on bone turnover of GH.
ISSN:0167-4889
1879-2596
DOI:10.1016/0167-4889(91)90145-N