Fibrinolytic response in malignancy

• Published in: Fibrinolysis Vol. 1; no. 3; pp. 195 - 199
• Main Authors: Páramo, J.A., Campbell, W., Cuesta, B., Gómez, C., Aranda, A., Rocha, E.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 1987
• Subjects: Fibrinolytic response; Malignancy; Plasminogen activator inhibitor activity (PA-inhibitor); Tissue-type plasminogen activator (t-PA); Fibrinolytic response; Plasminogen activator inhibitor activity (PA-inhibitor); Malignancy; Tissue-type plasminogen activator (t-PA)
• ISSN: 0268-9499
• DOI: 10.1016/0268-9499(87)90010-5

Fibrinolytic response was investigated in 71 patients with different malignancies and compared with findings in 30 healthy persons. Euglobulin lysis time, fibrinolytic activity on fibrin plate, tissue plasminogen activator (t-PA) activity and antigen before and after venous occlusion and the fast-acting inhibitor to t-PA (PA-inhibitor) were performed. Fifteen patients (21%) showed low fibrinolytic activity on fibrin plate after venous occlusion (low responders), whereas all control subjects showed a positive response (p < 0.03). t-PA activity was significantly lower in patients (p < 0.003) and t-PA antigen showed no significant differences between patients and controls in post-occlusion samples. PA-inhibitor was significantly higher in patients (p < 0.0002). We conclude that defective fibrinolysis in malignancy, resulting of highly increased PA-inhibitor levels in combination with low t-PA activity, and may have pathogenetic implications.