Virus-mediated inhibition of the ppp(A2′p) n A system and its prevention by interferon

Encephalomyocarditis virus infection of mouse Ehrlich ascites tumour or L-cells or human HeLa cells inhibits the activation of the ppp(A2′p) n A-dependent nuclease and prevents the binding of a radioactive analogue of ppp(A2′p) n A to the ppp(A2′p) n A binding protein. This loss or inactivation of t...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 104; no. 2; pp. 376 - 382
Main Authors Cayley, P.J., Knight, M., Kerr, I.M.
Format Journal Article
LanguageEnglish
Published Elsevier Inc 1982
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Summary:Encephalomyocarditis virus infection of mouse Ehrlich ascites tumour or L-cells or human HeLa cells inhibits the activation of the ppp(A2′p) n A-dependent nuclease and prevents the binding of a radioactive analogue of ppp(A2′p) n A to the ppp(A2′p) n A binding protein. This loss or inactivation of the ppp(A2′p) n A-dependent nuclease in response to virus infection is prevented by interferon pretreatment of the cells.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(82)90647-7