Heterocyclic corticosteroids: I. Biological properties of the 6, 16α-dimethyl-4, 6-pregnadiene-11β, 17, 21-triol-20-one/ phenylpyrazole-21-acetate and its 21-desoxy derivative

6,16α-Dimethyl-4, 6-pregnadiene-11β, 17, 21-triol-20-one ▪phenylpyrazole-21-acetate and its 21-desoxy derivative were evaluated in animals and in man for glucocorticoid activity. These compounds did not exhibit a significant separation of the biological activities measured in spite of their unique c...

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Published inSteroids Vol. 18; no. 2; pp. 129 - 139
Main Authors Steelman, S.L., Morgan, E.R., Glitzer, M.S.
Format Journal Article
LanguageEnglish
Published Elsevier Inc 1971
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Summary:6,16α-Dimethyl-4, 6-pregnadiene-11β, 17, 21-triol-20-one ▪phenylpyrazole-21-acetate and its 21-desoxy derivative were evaluated in animals and in man for glucocorticoid activity. These compounds did not exhibit a significant separation of the biological activities measured in spite of their unique chemical structure and high potency.
ISSN:0039-128X
1878-5867
DOI:10.1016/0039-128X(71)90020-1