Controversy and Consensus About Statin Use

Women without CVD have a lower annual mortality risk and lower CVD risk than men without CVD. [...]the absolute benefit of statins will typically be less for women than men, suggesting it might be appropriate that women receive statins less frequently than men in the setting of primary prevention. P...

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Bibliographic Details
Published inJournal of the American College of Cardiology Vol. 59; no. 6; pp. 583 - 584
Main Author Mosca, Lori, MD, MPH, PhD
Format Journal Article
LanguageEnglish
Published New York Elsevier Limited 07.02.2012
Subjects
Cardiology
Cardiovascular
Drug therapy
Internal Medicine
Meta-analysis
Mortality
Statins
Studies
cardiovascular disease
lipids
LDL
statins
women
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Summary:Women without CVD have a lower annual mortality risk and lower CVD risk than men without CVD. [...]the absolute benefit of statins will typically be less for women than men, suggesting it might be appropriate that women receive statins less frequently than men in the setting of primary prevention. Perhaps, but no data about individual baseline risk level were evaluated for potential sex differences in statin effectiveness; within each primary prevention population there might be substantial heterogeneity of risk. [...]the authors did not have enough data to critically evaluate adverse side effects, because only 2 studies provided sex-specific data.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2011.11.008