Starch‐Based Membranes for Controlled Release of 5‐Fluorouracil In Vitro

• Published in: ChemistrySelect (Weinheim) Vol. 6; no. 23; pp. 5678 - 5684
• Main Authors: Berkkan, Aysel, Kondolot Solak, Ebru, Asman, Gulsen
• Format: Journal Article
• Language: English
• Published: 21.06.2021
• Subjects: 5-fluorouracil; Drug delivery; Green chemistry; Polymer; Starch/PVA membrane
• ISSN: 2365-6549; 2365-6549
• DOI: 10.1002/slct.202100917

Starch is a natural polymer that is among the sustainable materials and has the characteristics of being a green material in harmony with nature. In this study, a potential transdermal release system was evaluated by investigating 5‐fluorouracil (5‐FU) transfer through starch/poly(vinyl alcohol) (PVA) membranes in vitro. The effects of membrane thickness, starch/PVA blending ratio, pH, and temperature on the release of 5‐FU from the membranes were studied. At the end of the study, it was deduced that decrease in pH reduces the released amount of 5‐FU from starch/PVA membranes and 5‐FU transfer from membranes could be controlled within a fairly constant range. The diffusion coefficient was determined as 4.84× 10−3, 4.49× 10−3 and 2.54× 10−3 cm2 s−1 for the pH of 7.4, 5.5, and 3.5, respectively. The activation energy for the permeation 5‐FU from starch/PVA membrane (60/40, v/v) was found to be 9.72 kJ mol−1. Starch/PVA membrane can be considered as an alternative membrane for the potential transdermal controlled release drug administration of 5‐FU. The diffusion coefficient of membrane (60/40, v/v) was determined as 4.84× 10−3, 4.49× 10−3, and 2.54× 10−3 cm2 s−1 at pH 7.4, 5.5, and 3.5, respectively.