Photodynamic Therapy Using Talaporfin Sodium for Cervical Intraepithelial Neoplasia

• Published in: Nihon Rēzā Igakkai shi Vol. 40; no. 4; pp. 381 - 385
• Main Authors: Murakami, Hirotake, Matsuya, Madoka, Adachi, Masashi, Itoh, Toshiya, Shibata, Toshiaki, Nakayama, Takeshi, Okazaki, Shigetoshi, Itoh, Hiroaki, Kanayama, Naohiro
• Format: Journal Article
• Language: English; Japanese
• Published: Japan Society for Laser Surgery and Medicine 15.01.2020
• Subjects: cervical cancer; Cervical intraepithelial neoplasia; Photodynamic therapy (PDT); photosensitivity; Talaporfin sodium
• ISSN: 0288-6200; 1881-1639
• DOI: 10.2530/jslsm.jslsm-40_0063

[Purpose] Cervical intraepithelial neoplasia (CIN) and early cervical cancer are frequently detected in women of reproductive age. The appropriate treatments for these diseases should be selected considering sparing fertility. Of these treatments, photodynamic therapy (PDT) is a minimally invasive therapeutic technique that enables sparing of the cervix and is as effective as cervical conization in terms of treatment results. Talaporfin sodium (NPe6)-mediated PDT was administered intravenously to nine CIN cases. This study aimed to evaluate the effect of PDT and photosensitivity in these cases.[Methods] PDT was administered to nine patients who were diagnosed with CIN based on cervical cytology, histology, and colposcopy findings. NPe6 was administered intravenously at a dose of 40 mg/m2. Four hours after the administration of NPe6, the patients were exposed to photoradiation (100 J/cm2).[Results] PDT was used to treat a total of nine patients (two patients with CIN2 and seven patients with CIN3). Cure was confirmed in eight cases who were available for follow up thorough examinations conducted at three and six months after photoradiation. Seven patients exhibited no photosensitivity at day 14 after NPe6 administration. Mild photosensitivity by direct sunlight test was observed in one patient up to day 28.[Conclusion] This study suggests that NPe6-mediated PDT might be a promising treatment for CIN.