Generation of Neutrophil Mediators During an Experimental Infection with Rhinovirus-16 in Asthmatic Patients

Cumulative values (summed over days 1-3 following RV inoculation) trended higher in asthmatics compared to controls (e.g., geometric means for NE=3775ng/mL and 2167ng/mL, respectively, p=0.45; MPO=1375ng/mL and 917.3ng/mL, p=0.66), but this trend was not apparent during resolution of the infection (...

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Published inJournal of allergy and clinical immunology Vol. 141; no. 2; p. AB111
Main Authors Sullivan, Robert A., Rajadhyaksha, Evan, Jorge, Patricia, Carper, Holliday T., Murphy, Deborah D., Platts-Mills, Thomas A.E., Heymann, Peter W.
Format Journal Article
LanguageEnglish
Published St. Louis Elsevier Inc 01.02.2018
Elsevier Limited
Subjects
Asthma
Experimental infection
Infections
Neutrophils
Rhinovirus
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ISSN0091-6749
1097-6825
DOI10.1016/j.jaci.2017.12.352

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Summary:Cumulative values (summed over days 1-3 following RV inoculation) trended higher in asthmatics compared to controls (e.g., geometric means for NE=3775ng/mL and 2167ng/mL, respectively, p=0.45; MPO=1375ng/mL and 917.3ng/mL, p=0.66), but this trend was not apparent during resolution of the infection (days 14 and 21). Conclusions During the early (innate) phase of the infection, a consistent trend in higher levels of neutrophil mediators was observed in nasal washes from asthmatic subjects compared to controls.
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ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.12.352