The Effect of Ligustrazine on Peritoneal Transport in Peritoneal dialysis

• Published in: Current medical science Vol. 22; no. 4; pp. 334 - 336
• Main Author: 朱忠华 彭维毅 等
• Format: Journal Article
• Language: English
• Published: China Department of Nephrology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430030 2002
• Subjects: Animals; Biological Transport; Cell Membrane Permeability; Creatinine - blood; Dialysis Solutions - chemistry; Peritoneal Dialysis - methods; Peritoneum - metabolism; Pyrazines - pharmacokinetics; Pyrazines - pharmacology; Rabbits; 川芎嗪; 腹腹运送; 腹膜透析; ligustrazine; peritoneal transport; peritoneal dialysis
• ISSN: 1672-0733; 2096-5230; 1993-1352; 2523-899X
• DOI: 10.1007/bf02896779

In order to investigate the effect of ligustrazine (Lig)i.p.on peritoneal permeability in peritoneal dialysis and its side effects,creatinine was given intravenously and continuously to maintain the high plasma creatinine level.All the rabbits were divided into three groups:normal control group (goup A),group B treated with 0.12% Lig and group C treated with 0.24% Lig.The peritoneal dialysis of all rabbits lasted 2h.The plasma and dialysate levels of glucose,protein and creatining were observed immediate,30min,60min,90min,120min after dialysis.Creastinine dialysate/plasma ratio (D/P),protein D/P ratio,grucose D/Do at different time points after dialysis and creatinine mass transfer area coefficient (MTAC) at 120min were calculated.The structures of peritoneum were observed under optical microscope and electron microscope after continuously intraperitoneal injection of Lig for 14 days.The results showed that the 90-min and 12-min creatinine D/P ratios in the group C were higher than in the group A.The 120-min creatinine MATC in the group C was higher than in the group A.The rabbits treated with Lig did not show significant structure changes of peritoneum and signs of peritoneal irritation.It was suggested that Lig could increase mass transfer ability of peritoneum without significant side effects.