Estimation of Na-blocking efficiency of rihlocaine and its combinations with low-molecular-weight polymers on isolated rat cardiomyocytes

The effect of glucose-base polymers (dextrans with relative molecular weight 10, 40, and 70 kD) and vinylpyrrolidone (polyvinylpyrrolidone: 10, 24, and 40 kD) on changes in the sarcoplasmic Na^sup +^ concentration in stimulated cardiomyocytes (1.0 Hz, 10 msec, 60 mV) were examined. In the concentrat...

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Published inBulletin of experimental biology and medicine Vol. 124; no. 6; pp. 1197 - 1199
Main Authors Khankoeva, A. I., Dukhanin, A. S., Galenko-Yaroshevskii, P. A., Reznikov, A. Yu
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.12.1997
Subjects
Cardiomyocytes
Efficiency
Polymers
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Summary:The effect of glucose-base polymers (dextrans with relative molecular weight 10, 40, and 70 kD) and vinylpyrrolidone (polyvinylpyrrolidone: 10, 24, and 40 kD) on changes in the sarcoplasmic Na^sup +^ concentration in stimulated cardiomyocytes (1.0 Hz, 10 msec, 60 mV) were examined. In the concentration range of 1-100 μM, the polymer preparations produced cardioprotective effect on cells incubated under hypoxic conditions; the effect depended on the nature and molecular weight of the polymer. Rihlocaine (25 μM) inhibits by 42% elevation of intracellular Na^sup +^ induced by plasma membrane depolarization. Dextran 40 is shown to significantly increase Na-blocking effect of rihlocaine.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02445118