Changes in blood-brain barrier permeability and expression of related factors in a rat model of intracerebral hemorrhage following minocycline treatment

• Published in: Neural regeneration research Vol. 5; no. 17; pp. 1308 - 1312
• Main Author: Wei Shi Zizhang Wang Jingnan Pu Ruizhi Wang Zhenyu Guo Chongxiao Liu Jianjun Sun Ligui Gao Ren Zhou
• Format: Journal Article
• Language: English
• Published: Department of Neurosurgery,Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,Shaanxi Province,China 15.09.2010
• Subjects: 大鼠模型; 热休克蛋白70; 神经生长因子; 脑出血; 血管内皮生长因子; 血脑屏障; 表达变化; 通透性; blood-brain barrier; intracerebral hemorrhage; heat shock protein 70; nerve growth factor; vascular endothelial growth factor; therapy
• ISSN: 1673-5374
• DOI: 10.3969/j.issn.1673-5374.2010.17.005

Inflammatory factor aggregation and blood-brain barrier（BBB）damage occur around hematoma foci following intracerebral hemorrhage.Minocycline is lipophilic,can pass through the BBB,and shows anti-inflammatory effects in models of central nervous system disease.We found that minocycline application at 6 hours after intracerebral hemorrhage reduced BBB permeability,decreased vascular endothelial growth factor expression,and increased nerve growth factor and heat shock protein 70 expression,primarily in neurons and microglia.Early intraperitoneal injection of minocycline attenuated BBB damage possibly by reducing vascular endothelial growth factor expression and enhancing nerve growth factor and heat shock protein 70 expression.