Therapeutic potentials and targeting strategies of quercetin on cancer cells: Challenges and future prospects

• Published in: Phytomedicine (Stuttgart) Vol. 133; p. 155902
• Main Authors: Rajesh R, Udaya, Sangeetha, Dhanaraj
• Format: Journal Article
• Language: English
• Published: Elsevier GmbH 01.10.2024
• Subjects: Anti-cancer activity; Drug delivery; Mechanism; Nanoparticles; Quercetin; Bcl-2; TPA; RAS; Anti-cancer activity; PTEN; Drug delivery; PARP; LRP; Mechanism; HPV; Nanoparticles; CCNB2; NF-κB; CCNB1; CASP8; PI3K; TERT; GSK3; CASP3; mTOR; JAK2; LC3; PSA; PLD-1; VEGF; Akt; Survivin; MAPK; O-GlcNAc; P53; PA; STAT; MMP-2; P38; Quercetin; ROS; Bax; CDK1; PK; MMP-9; ERK
• ISSN: 0944-7113; 1618-095X; 1618-095X
• DOI: 10.1016/j.phymed.2024.155902

Every cell in the human body is vital because it maintains equilibrium and carries out a variety of tasks, including growth and development. These activities are carried out by a set of instructions carried by many different genes and organized into DNA. It is well recognized that some lifestyle decisions, like using tobacco, alcohol, UV, or multiple sexual partners, might increase one's risk of developing cancer. The advantages of natural products for any health issue are well known, and researchers are making attempts to separate flavonoid-containing substances from plants. Various parts of plants contain a phenolic compound called flavonoid. Quercetin, which belongs to the class of compounds known as flavones with chromone skeletal structure, has anti-cancer activity. The study was aimed at investigating the therapeutic action of the flavonoid quercetin on various cancer cells. The phrases quercetin, anti-cancer, nanoparticles, and cell line were used to search the data using online resources such as PubMed, and Google Scholar. Several critical previous studies have been included. Quercetin inhibits various dysregulated signaling pathways that cause cancer cells to undergo apoptosis to exercise its anticancer effects. Numerous signaling pathways are impacted by quercetin, such as the Hedgehog system, Akt, NF-κB pathway, downregulated mutant p53, JAK/STAT, G1 phase arrest, Wnt/β-Catenin, and MAPK. There are downsides to quercetin, like hydrophobicity, first-pass effect, instability in the gastrointestinal tract, etc., because of which it is not well-established in the pharmaceutical industry. The solution to these drawbacks in the future is using bio-nanomaterials like chitosan, PLGA, liposomes, and silk fibroin as carriers, which can enhance the target specificity of quercetin. The first section of this review covers the specifics of flavonoids and quercetin; the second section covers the anti-cancer activity of quercetin; and the third section explains the drawbacks and conjugation of quercetin with nanoparticles for drug delivery by overcoming quercetin's drawback. Overall, this review presented details about quercetin, which is a plant derivative with a promising molecular mechanism of action. They inhibit cancer by various mechanisms with little or no side effects. It is anticipated that plant-based materials will become increasingly relevant in the treatment of cancer. [Display omitted]