Plasma membrane signal-transducing ATP

Plasma membranes of target cells generate considerable amounts of ATP in response to binding of growth factors, cytokines, and oncoproteins. Plasma membrane ATP is formed at the stage of ligand-receptor signal transduction by the anaerobic pathway with the involvement of plasma membrane redox system...

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 128; no. 1; pp. 661 - 667
Main Authors Karelin, A. A., Globa, A. G., Demidova, V. S.
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.07.1999
Subjects
Cells
Cytokines
Ligands
Plasma
Proteins
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Summary:Plasma membranes of target cells generate considerable amounts of ATP in response to binding of growth factors, cytokines, and oncoproteins. Plasma membrane ATP is formed at the stage of ligand-receptor signal transduction by the anaerobic pathway with the involvement of plasma membrane redox systems and Na^sup +^ (but not adenylate cyclase). The assumption on the involvement of transitory reversed Na^sup +^, K^sup +^-ATPase in the synthesis of plasma membrane ATP is confirmed by inhibitory analysis. ATP-producing activity of plasma membrane-enriched particles isolated from various target cells in response to various growth factors was studied. The formation of plasma membrane ATP is stimulated by growth factors and cytokines interacting with integral tyrosine kinase receptors or soluble tyrosine kinases in the cytosol. Various tyrosine kinase inhibitors act by utilizing plasma membrane ATP. Plasma membrane ATP is assumed to be a messeger and amplifier of ligand-receptor signals in plasma membranes of animal cells.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02433307