Psychostimulant effect of synthetic dermorphin analog

The effect of a dermorphin analog on learning was studied in a Wistar rat model of the complex food-seeking task. The preparation decreased the degree of anxiety in a dose-independent manner. In a dose of 50 μg/kg it increased the number of "well"-learning rats by intensifying the learning...

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Published inBulletin of experimental biology and medicine Vol. 126; no. 3; pp. 866 - 868
Main Authors Eshchenko, O. V., Nikol'skaya, K. A., Deigin, V. I., Yarova, E. P.
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.09.1998
Subjects
Rodents
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Summary:The effect of a dermorphin analog on learning was studied in a Wistar rat model of the complex food-seeking task. The preparation decreased the degree of anxiety in a dose-independent manner. In a dose of 50 μg/kg it increased the number of "well"-learning rats by intensifying the learning process in rats with initially suppressed cognitive activity. In a dose of 150 μg/kg, the opioid decreased the number of "well"-learning rats due to disturbance of motivation mechanisms, which was manifested in behavioral instability.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02447359