The relationship between prostate volume, prostate-specific antigen and age in Saudi men with benign prostatic conditions

• Published in: African journal of urology Vol. 16; no. 4; pp. 117 - 123
• Main Authors: Mosli, H. A., Abdel-Meguid, Taha Abo-Almagd
• Format: Journal Article
• Language: English
• Published: Paris Springer-Verlag 01.01.2010
• Subjects: Imaging; Medicine; Medicine & Public Health; Original Article; Radiology; Surgery; Urology; volume; Saudi Arabia; prostate specific antigen; Prostate; prostatic hyperplasia
• ISSN: 1110-5704; 1961-9987
• DOI: 10.1007/s12301-010-0025-4

Objectives To assess the relationship between prostate volume (PV), prostate specific antigen (PSA) and age in a cohort of Saudi men from the Urology Department, King Abdul Aziz University Hospital, Jeddah, Saudi Arabia. Methods Medical records of 447 Saudi men aged 20–89 years with benign prostatic conditions seen between January 2003 and June 2009, were reviewed, retrospectively. Cases with PSA >10 ng/ml, proven prostate cancer, previous prostate surgery or those who received 5-alpha reductase inhibitors (5-ARIs) were excluded. The study population was categorized into seven successive age groups (20–89 years). The variables of age, PV and PSA were examined. Using mean PV of the 20–29 years age group and mean PSA of the 40–49 years age group as reference points, percentage differences in mean PV and mean PSA in subsequent age groups were determined. A p-value <0.05 was considered significant. Findings in Saudi patients were compared to other ethnicities. Results 447 men were enrolled with mean age 64.2 years, mean PV 35.2 cc (range 7–184 cc) and mean PSA 2.2 ng/ml (range 0.18–10 ng/ml). Overall, 62% (277/447) had PV <30 cc and 8.7% (39/447) had PV ≥50 cc. Among individual age groups, most men had PV <30 cc, except the 70–79 years age group where 55.2% (53/96) had PV >30 cc. Percentage differences of PV and PSA in 80–89 years age group (+150% and +70%, respectively) were lower than in the 60–69 and 70–79 years age groups (+187% and +160%; +207.2% and +220% for PV and PSA, respectively). All variables demonstrated significant weak correlations; except PV and PSA which showed a significant positive relationship (p <0.0001; r=0.441). Conclusion PV and PSA are significantly and strongly correlated. PV and PSA in Saudi men are closer to Asian than white ethnicities.