Effect of dithiothreitol on cardiomyocyte ultrastructure in the prooxidant zone of rat heart in experimental cardiac failure

Compensatory and degenerative structural changes in rat cardiomyocytes are demonstrated. Lipid peroxidation plays a major role in the degenerative processes in the prooxidant zone. In rats with experimental cardiac failure treated with dithiothreitol, compensatory and repair changes predominate in t...

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 123; no. 4; pp. 344 - 348
Main Authors Chernysh, I. N., Sadovnikov, V. B.
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.04.1997
Subjects
Calcium
Cardiomyocytes
Heart failure
Rodents
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Summary:Compensatory and degenerative structural changes in rat cardiomyocytes are demonstrated. Lipid peroxidation plays a major role in the degenerative processes in the prooxidant zone. In rats with experimental cardiac failure treated with dithiothreitol, compensatory and repair changes predominate in the prooxidant zone cardiomyocytes. Ultrahistochemical analysis shows that administration of dithiothreitol restores ATPase activity of the sarcoplasmic reticulum.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02766182