Growth-inhibitory activity of bone marrow cells during CCl4-induced liver cirrhosis

During CCl^sub 4^-induced liver cirrhosis, cells of the hemopoiesis-inducing microenvironment in the bone marrow of BALB/c mice produced activity inhibiting the growth of erythropoiesis and granulomonocytopoiesis precursors. Stimulation with yeast polysaccharide zymosan increased the inhibitory acti...

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 127; no. 6; pp. 587 - 589
Main Authors Zubakhin, A. A., Kutina, S. N.
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.06.1999
Subjects
Bone marrow
Liver cirrhosis
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Summary:During CCl^sub 4^-induced liver cirrhosis, cells of the hemopoiesis-inducing microenvironment in the bone marrow of BALB/c mice produced activity inhibiting the growth of erythropoiesis and granulomonocytopoiesis precursors. Stimulation with yeast polysaccharide zymosan increased the inhibitory activity (especially in relation to granulomonocytic precursors). The highest growth-inhibitory activity was produced by the bone marrow adherent fraction (residual bone marrow macrophages). Tumor necrosis factor-α is probably responsible for the inhibition of the growth of myeloid precursors in mice with CCl^sub 4^-induced liver cirrhosis.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02433285