Swelling studies and in vitro release of acemetacin and BSA from alginate gel beads crosslinked with Ca2+ or Ba2
The aim of the present work was to investigate the swelling behavior and the in vitro release of acemetacin and bovine serum albumin from alginate gel beads crosslinked with Ca 2+ or Ba 2+ . The release profiles suggested that the extent of swelling of the alginate beads played an important role in...
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| Published in | Journal of Wuhan University of Technology. Materials science edition Vol. 27; no. 4; pp. 669 - 674 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Heidelberg
Wuhan University of Technology
01.08.2012
|
| Subjects | |
| Online Access | Get full text |
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| Abstract | The aim of the present work was to investigate the swelling behavior and the in vitro release of acemetacin and bovine serum albumin from alginate gel beads crosslinked with Ca
2+
or Ba
2+
. The release profiles suggested that the extent of swelling of the alginate beads played an important role in the release of drug. Small drugs are mainly released via diffusion through the alginate gel matrix. Compared with small drugs, large molecule drugs are difficult to diffuse through the pores of the matrix bead until the beads swell to a certain extent to provide enough large pores. The Ba
2+
crosslinked alginate beads showed slower release rate compared with the Ca
2+
crosslinked alginate beads, whether loaded the large molecules or small drugs. In conclusion, the Ba
2+
crosslinked alginate beads are considered more suitable than Ca
2+
crosslinked alginate beads for using as a sustained release vehicle especially for large molecule drugs. |
|---|---|
| AbstractList | The aim of the present work was to investigate the swelling behavior and the in vitro release of acemetacin and bovine serum albumin from alginate gel beads crosslinked with Ca
2+
or Ba
2+
. The release profiles suggested that the extent of swelling of the alginate beads played an important role in the release of drug. Small drugs are mainly released via diffusion through the alginate gel matrix. Compared with small drugs, large molecule drugs are difficult to diffuse through the pores of the matrix bead until the beads swell to a certain extent to provide enough large pores. The Ba
2+
crosslinked alginate beads showed slower release rate compared with the Ca
2+
crosslinked alginate beads, whether loaded the large molecules or small drugs. In conclusion, the Ba
2+
crosslinked alginate beads are considered more suitable than Ca
2+
crosslinked alginate beads for using as a sustained release vehicle especially for large molecule drugs. |
| Author | Zhang, Liangke Zhang, Jingqing Hu, Wenjing Wang, Chengyuan Yuan, Pei Jia, Yuntao |
| Author_xml | – sequence: 1 givenname: Pei surname: Yuan fullname: Yuan, Pei organization: Institute of Life Science, Chongqing Medical University – sequence: 2 givenname: Yuntao surname: Jia fullname: Jia, Yuntao organization: Department of Pharmacy, Children’s Hospital of Chongqing Medical University – sequence: 3 givenname: Liangke surname: Zhang fullname: Zhang, Liangke email: zlkdyx@gmail.com organization: Institute of Life Science, Chongqing Medical University, Chongqing Key Laboratory of Biochemistry & Molecular Pharmacology, School of pharmacy, Chongqing Medical University – sequence: 4 givenname: Jingqing surname: Zhang fullname: Zhang, Jingqing organization: Chongqing Key Laboratory of Biochemistry & Molecular Pharmacology, School of pharmacy, Chongqing Medical University – sequence: 5 givenname: Wenjing surname: Hu fullname: Hu, Wenjing organization: Chongqing Xijiao Hospital – sequence: 6 givenname: Chengyuan surname: Wang fullname: Wang, Chengyuan organization: Research Center of Medical Chemistry & Chemical Biology, Chongqing Technology and Business University |
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| CitedBy_id | crossref_primary_10_1016_j_foodchem_2021_130902 crossref_primary_10_1016_j_jmbbm_2019_01_019 crossref_primary_10_1002_jbm_a_36539 crossref_primary_10_1002_app_40650 crossref_primary_10_1007_s11595_016_1545_y crossref_primary_10_3109_03639045_2014_893355 crossref_primary_10_1016_j_carbpol_2019_115617 crossref_primary_10_3109_03639045_2015_1088866 |
| Cites_doi | 10.1111/j.1749-6632.2001.tb03836.x 10.1016/j.ejps.2006.06.008 10.1016/S0169-409X(97)00124-5 10.1016/j.ijpharm.2006.05.054 10.1016/S0168-3659(98)00096-0 10.1016/S0168-3659(01)00517-X 10.1163/156856209X416449 10.1016/S0378-5173(02)00553-7 10.3168/jds.S0022-0302(01)74572-9 10.1016/S1051-0443(07)61344-X 10.1016/j.ijpharm.2006.12.019 10.2174/1567201043334803 10.1023/A:1018869601502 10.1080/02652040010019578 10.1021/bm060010d 10.1016/j.ejps.2004.12.004 10.1016/j.ijpharm.2009.10.016 10.1021/js9604117 10.1016/S0168-3659(98)00141-2 10.1016/S1389-1723(99)80207-2 10.1177/096368970000900604 |
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| Title | Swelling studies and in vitro release of acemetacin and BSA from alginate gel beads crosslinked with Ca2+ or Ba2 |
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