Swelling studies and in vitro release of acemetacin and BSA from alginate gel beads crosslinked with Ca2+ or Ba2

The aim of the present work was to investigate the swelling behavior and the in vitro release of acemetacin and bovine serum albumin from alginate gel beads crosslinked with Ca 2+ or Ba 2+ . The release profiles suggested that the extent of swelling of the alginate beads played an important role in...

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Bibliographic Details
Published inJournal of Wuhan University of Technology. Materials science edition Vol. 27; no. 4; pp. 669 - 674
Main Authors Yuan, Pei, Jia, Yuntao, Zhang, Liangke, Zhang, Jingqing, Hu, Wenjing, Wang, Chengyuan
Format Journal Article
LanguageEnglish
Published Heidelberg Wuhan University of Technology 01.08.2012
Subjects
Chemistry and Materials Science
Materials Science
BSA
calcium ions
acemetacin
release
alginate beads
barium ions
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Summary:The aim of the present work was to investigate the swelling behavior and the in vitro release of acemetacin and bovine serum albumin from alginate gel beads crosslinked with Ca 2+ or Ba 2+ . The release profiles suggested that the extent of swelling of the alginate beads played an important role in the release of drug. Small drugs are mainly released via diffusion through the alginate gel matrix. Compared with small drugs, large molecule drugs are difficult to diffuse through the pores of the matrix bead until the beads swell to a certain extent to provide enough large pores. The Ba 2+ crosslinked alginate beads showed slower release rate compared with the Ca 2+ crosslinked alginate beads, whether loaded the large molecules or small drugs. In conclusion, the Ba 2+ crosslinked alginate beads are considered more suitable than Ca 2+ crosslinked alginate beads for using as a sustained release vehicle especially for large molecule drugs.
ISSN:1000-2413
1993-0437
DOI:10.1007/s11595-012-0526-z