Drug discovery research using AI and data science: analyzing literature information to understand pathological mechanisms

• Published in: Nihon yakurigaku zasshi Vol. 158; no. 1; p. 3
• Main Authors: Nozawa, Katsura, Tsunoyama, Kazuhisa
• Format: Journal Article
• Language: Japanese
• Published: Japan 2023
• Subjects: Artificial Intelligence; Data Science
• ISSN: 0015-5691
• DOI: 10.1254/fpj.22062

Recent rapid progress in big data and breakthrough AI technologies have brought about significant changes in the medical field as well. Although biomedical literature databases contain so many articles that it is impossible to read them all, AI technology based on neural networks has dramatically advanced and is now able to efficiently process such vast amounts of literature information in a short time. Since drug discovery research requires up-to-date and extensive knowledge of various disciplines, it is necessary to proactively incorporate AI technology to seamlessly obtain the information needed. In this article, we introduce our effort to use the rapidly growing literature data and the latest AI technologies to drug discovery research. Conventional search engines take an enormous amount of time to identify and understand sentences describing the subject matter of interest in the retrieved articles. We developed and validated our new search tool that not only has a conventional keyword search function, but also enables conceptual search for disease mechanisms using sentences. We will also describe problems that we have identified through actual use of the tool. Finally, since literature data is expected to increase and efforts to determine how to efficiently analyze and obtain desired findings using AI will become even more active, we will discuss expectations for future technological advances and issues that need to be resolved.