Diabetic neuropathy models: Are they relevant?

Diabetic neuropathy has been studied using a variety of in vitro models, induced in vivo models such as the streptozotocin or alloxan treated rodent, and many different genetic models representing Type I or Type II diabetes. These models have been used to investigate the pathogenesis of neuropathy,...

Full description

Saved in:
Bibliographic Details
Published inDrug discovery today. Disease models Vol. 3; no. 4; pp. 397 - 402
Main Author Apfel, Stuart C.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.12.2006
Online AccessGet full text

Cover

More Information
Summary:Diabetic neuropathy has been studied using a variety of in vitro models, induced in vivo models such as the streptozotocin or alloxan treated rodent, and many different genetic models representing Type I or Type II diabetes. These models have been used to investigate the pathogenesis of neuropathy, and for testing experimental treatments. Most differ from the clinical condition to varying degrees, yet serve as useful tools for scientists who recognize their limitations. Kathryn Albers – University of Pittsburgh, Pittsburgh, USA
ISSN:1740-6757
1740-6757
DOI:10.1016/j.ddmod.2006.10.014