Comparative study of Na-blocking properties of antiarrhythmic drugs on isolated rat cardiomyocytes

The effects of the antiarrhythmic preparations lidocaine, flecainide, and rhlocaine on sodium concentration in cardiomyocyte cytoplasm are studied using the Na-sensitive fluorescent probe SBFI. The Na-blocking effect of lidocaine and rihlocaine depends on the frequency of electrical stimulation of c...

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 123; no. 6; pp. 579 - 581
Main Authors Khankoeva, A. I., Dukhanin, A. S., Galenko-Yaroshevskii, P. A.
Format Journal Article
LanguageEnglish
Published New York Springer Nature B.V 01.06.1997
Subjects
Arrhythmia
Cardiomyocytes
Cytoplasm
Electrical stimuli
Fluorescent indicators
Lidocaine
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Summary:The effects of the antiarrhythmic preparations lidocaine, flecainide, and rhlocaine on sodium concentration in cardiomyocyte cytoplasm are studied using the Na-sensitive fluorescent probe SBFI. The Na-blocking effect of lidocaine and rihlocaine depends on the frequency of electrical stimulation of cardiomyocytes (0.2–1.0 Hz). The data suggest the possibility ofin vitro testing of novel antiarrhythmic drugs.
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02458083